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The Portofino Instant Lift Serum by Prato Botanico is the focus of Kelly's video review. Kelly highlights the unique ball applicator of the serum, which allows for easy and precise application. The serum is designed to be applied to wrinkles and promises an instant lifting effect. Kelly even notices a visible smoothing effect on her skin. Overall, Kelly recommends giving this serum a try, suggesting that it delivers on its claims. With its innovative applicator and noticeable results, the Portofino Instant Lift Serum by Prato Botanico seems to be a promising addition to any skincare routine.