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The A Defiance A Eye XR by Serious Skincare is a time-released nano-encapsulated retinol eye cream concentrate that Nicole has been using for a few days. Despite having sensitive and dry skin, she hasn't experienced any irritation. Nicole applies the cream under her eyes and follows up with her regular eye cream, without any issues of pilling or pulling away of her concealer. She appreciates the gentle and time-released formula of the encapsulated retinol, which is beneficial for the delicate under-eye area. Overall, Nicole's initial experience with the A Defiance A Eye XR has been positive, with no drawbacks mentioned.